Birla Institute of Technology, Mesra
   
Dr. Biswatrish Sarkar
Assistant Professor, Pharmaceutical Sciences and Tech
M. Pharm., Ph.D., R.Ph.
Contact Address
Permanent Address C/O Mr. Biresh Chandra Sarkar. 100/2 Jaigirghat Road. Thakurpukur. Kolkata: 700063
Local Address Quarter No: CII/23. Beside Dispensary. Birla Institute of Technology, Mesra. Ranchi: 835215
Phone (Office) 06512275444 (extn. 423)
Phone Residence --
Email Id biswatrishsarkar@bitmesra.ac.in
Joined Institute on : 9-Jul-2007
  Work Experience
 
Teaching : 16 Years

Research : 11 Years

  Professional Background
  1. Assistant Professor of Pharmaceutical Sciences in B.I.T, Mesra, Ranchi since 9th July 2007 to till date.
  2. Worked as a Lecturer in Royal College of Pharmacy & Health Sciences, Berhampur, Orissa from 12th July 2005 till 3rd July 2007.  
  Research Areas
 
  1. Oxidative stress and Antioxidants
  2. Cardiometabolic properties of polyphenols
  3. Hepatoprotective properties of polyphenols
  4. Dengue virus protease inhibitors
  Award and Honours
 
  1. 2002: Qualified GATE (Pharmacy)
  2. 2015: DBT-CTEP International Travel Fellowship by Department of Biotechnology,Government of India. 
  3. 2015: International Travel Fellowship by Centre for International Co-operation in Sciences (CICS),Chennai, India.
   Publications
 

 Journals (17):

  Google Scholar Citations: 100; h-index: 5; i10 index: 3

  Scopus Citations: 74; h-index: 5

  1. Chatterjee, A., Saha,R., Mishra,A., Shilkar, D., Jayaprakash, V. Sharma,P., Sarkar, B. (2022). Molecular determinants, clinical manifestations and effects of immunization on cardiovascular health during COVID-19 pandemic era - A review, Current Problems in Cardiology, 101250, https://doi.org/10.1016/j.cpcardiol.2022.101250(Impact factor 5.2)
  2. Das, N., Deb, P. K., Ali, E. S., Das, M. C., Sarkar, B., & Mishra, S. K. (2022). Anti-Proliferative Naphthalene Glucoside from Aerial Part of Neanotis wightiana. Chemistry of Natural Compounds, 58(1), 21-26. https://doi.org/10.1007/s10600-022-03591-3 (Impact factor 0.809)
  3. Murtuja S., Shilkar D., Sarkar B., Sinha B.N., Jayaprakash V. (2021). A Critical Observation on the Design and Development of Reported Peptide Inhibitors of DENV NS2B-NS3 Protease in the Last Two Decades. Mini-Reviews in Medicinal Chemistry. DOI: 10.2174/1389557521666211101154619. (Impact factor 3.862) 
  4. Murtuja S., Shilkar D., Sarkar B., Sinha B.N., Jayaprakash V. (2021). A short survey of Dengue protease inhibitor development in the past 6 years (2015-2020) with an emphasis on similarities between DENV and SARS-CoV-2 proteases. Bioorganic & Medicinal Chemistryhttps://doi.org/10.1016/j.bmc.2021.116415(Impact factor 3.641)
  5. Deb, P. K. and Sarkar, B. (2021). Seasonal variation of verbascoside as a principal phenolic compound linked with antioxidant potentials of Clerodendrum glandulosum Lindl. leaves. Natural Product Research. https://doi.org/10.1080/14786419.2021.1979542. (Impact factor 2.861)
  6. Deb, P. K., Khound, P., Bhattacharjee, S., Choudhury, P., Sarma, H., Devi, R., Sarkar, B. (2021). Variation in chemical constituents, in-vitro bioactivity and toxicity profile
    among different parts of Clerodendrum glandulosum Lindl. (C. colebrookianum Walp.). South African Journal of Botany 140 (2021) 50-61. https://doi.org/10.1016/j.sajb.2021.03.023 (Impact factor 2.315) 
  7. Adhikary, M., Mukhopadhyay, K., Sarkar, B. (2021) Flavonoid-rich wheatgrass (Triticum aestivum L.) diet attenuates diabetes by modulating antioxidant genes in streptozotocin- induced diabetic rats. Journal of Food Biochemistry. 2021;00:e13643. https://doi.org/10.1111/jfbc.13643 (Impact factor 2.72)
  8. Roy, A., Sarkar, B., Celik, C., Ghosh, A., Basu, U, Jana, M., Jana, A., Gencay, A., Sezgin, G. C., Ildiz, N., Dam, P., Mandal, A. K., Ocsoy, I. (2020). Can concomitant use of zinc and curcumin with other immunity-boosting nutraceuticals be the arsenal against COVID-19? Phytotherapy Research. 1-4. DOI: 10.1002/ptr.6766 (Impact factor 5.878)
  9. Sarkar, B., Vyas,P., Haque,I., Mukhopadhyay, K. (2018). A rapid UPLC method for simultaneous separation and detection of anthocyanidins from OcimumHibiscus and Syzygium species and estimation of their antioxidant activity. Journal of Liquid Chromatography & Related Technologies, 41(10), 658–667 (https://doi.org/10.1080/10826076.2018.1506932) (Impact factor 1.312). 
  10. Soni, S.R., Kumari, N., Bhunia, B. K., Sarkar, B., Mandal, B., Ghosh, A. (2018). Synthesis and characterization of a non-cytotoxic and biocompatible acrylamide grafted pullulan- Application in pH responsive controlled drug delivery.International Journal of Biological Macromolecules, 120, 753-762. (Impact factor 6.953
  11. Soni, S.R., Kumari, N., Bhunia, B. K., Sarkar, B., Mandal, B., Ghosh, A. (2018). In vitro and in vivo evaluation of pirfenidone loaded acrylamide grafted pullulan-poly(vinyl alcohol) interpenetrating polymer networks. Carbohydrate Polymers, 202, 288-298. (Impact factor 9.381) 
  12. Singh, S., Sarkar, B., Mukhopadhyay, K., Banerjee, M., Kumar, M. (2018). Antioxidants, DNA damage protective properties and antibacterial activity of leaf extract of Phlogacanthus thyrsiflorus Nees. Asian Journal of Microbiology Biotechnology and Environmental Sciences, 20, S145-S151. (SCOPUS - H Index - 13).
  13. Adhikary, M., Sarkar, B., Mukhopadhyay, K. (2017). Identification of flavonoids of Wheatgrass (Triticum aestivum L.) at various stages 
    of growth and evaluation of their Antioxidant Activity. Canadian Journal of Biotechnology, Volume 1, Special Issue, Page 159. (https://doi.org/10.24870/cjb.2017-a145)
  14. Sarkar, B., Kumar, D., Sasmal, D., Mukhopadhyay, K. (2014). Antioxidant and DNA damage protective properties of anthocyanin-rich extracts from Hibiscus and Ocimum: a comparative study. Natural Product Research, 28 (17), 1393-1398. (Impact factor 2.861) 
  15. Panda, A. B., Laha, P., Harish, K.,  Sarkar, B., Chaure, S.V., Sayyad, W.A., Jadhav, V.S., Kulkarni, G.R., Sasmal, D., Barhai, P. K., Das, A. K., Mahapatra, S. K., Banerjee, I. (2010). Study of bactericidal efficiency of magnetron sputtered TiO2 films deposited at varying oxygen partial pressure. Surface & Coatings Technology, 205,1611–1617 (Impact factor 4.158).
  16. Mani, M., Vaibhav, D. A., Sarkar, B., Dev, A., Ashok, Patra, A. (2008). Antibacterial Activity of the Leaves of Abutilon indicum Linn. PHARMBIT, Vol.XVII, No.1, Jan-Jun. 
  17. Sarkar, B (2004). Bioinformatics- A Glimpse; PHARMBIT, 13, 38-41
 
Presentations in International Conferences (11):
  1. Chatterjee, A., Deb, P. K., Sarkar, B. Influence of solvents and techniques for extraction of phenolic phytochemicals linked with antioxidant and enzyme inhibition potential of Ocimum tenuiflorum Linn. 7th International Electronic Conference on Medicinal Chemistry (ECMC-2021). Organized by MDPI: Basel, Switzerland. Dated: November 1–30, 2021. https://doi.org/10.3390/ECMC2021-11461.
  2. Saha, R., Sarkar, B. Unveiling the therapeutic potential of verbascoside to combat diabetic wound. 7th International Electronic Conference on Medicinal Chemistry (ECMC-2021). Organized by MDPI: Basel, Switzerland. Dated: November 1–30, 2021. https://doi.org/10.3390/ECMC2021-11476
  3. Deb, P. K., Chatterjee, A., Saha, R., Sarkar, B. Influence of choice of solvents and extraction techniques on the recovery of phenolic phytochemicals linked to the antioxidant and enzyme inhibition potential of Clerodendrum glandulosum Lindl. “XXX International Conference on Polyphenols”. Organized Virtually by University of Turku, Finland. Dated: July 13-15, 2021 (P.4.6).
  4. Priya, S., Chatterjee, A., Deb, P. K., Sarkar, B. Influence of solvents and extraction techniques on the recovery of secondary metabolites and antioxidant properties of Ocimum tenuiflorum Linn. “7th International Congress of Society for Ethnopharmacology” Organized by Bioactive Natural Product Laboratory (BNPL), School of Pharmaceutical Education and Research, Jamia Hamdard University. Dated: February 15-17, 2020 (OP-67).
  5. Deb, P.K., Sarkar, B. Novel phytopharmaceutical derived from leaves of Clerodendrum colebrookianum Walp. exhibits hepatoprotective and antidiabetic potential. “9th International Conference on Polyphenols and Health (ICPH2019)” Organized by Polyphenol Society, Japan at Kobe Convention Center, Kobe, Japan. Dated: November 28 -December 1, 2019.
  6. Deb, P. K., Sarkar, B. Development of chromatographic signature and metabolomics profile of Ocimum tenuiflorum (Krishna Tulsi) for the purpose of quality control. “6th International Congress of Society for Ethnopharmacology” Organized by Manipal College of Pharmaceutical Sciences, MAHE, Manipal. Dated: February 08-10, 2019 (A-92).
  7. Sarkar, B. Anthocyanins from flowers of Hibiscus rosa-sinensis modulate biomarkers of oxidative stress via up-regulation of antioxidant responsive genes. “6th International Congress of Society for Ethnopharmacology” Organized by Manipal College of Pharmaceutical Sciences, MAHE, Manipal. Dated: February 08-10, 2019 (A-83).
  8. Adhikary, M., Sarkar, B. and Mukhopadhyay, K. Identification of flavonoids of Wheatgrass (Triticum aestivum L.) at various stages of growth and evaluation of their Antioxidant Activity [Abstract]. Nextgen Genomics, Biology, Bioinformatics and Technologies Conference; Oct 02-04, 2017; Bhubaneswar, Odisha. Odisha. (https://doi.org/10.24870/cjb.2017-a145). 
  9. Sarkar, B. & Mukhopadhyay, K. A comparative study of in-vitro and in-vivo antioxidant activity and DNA protective properties of anthocyanins from Ocimum and Hibiscus species. “8th International Workshop on Anthocyanins -2015”, Organized by INRA, Montpellier, France. Dated: September 16-18, 2015. (S3-P28, Page No. 84).
  10. Sarkar, B., Vyas, P., Chaudhary, B., Haque, I., Kumar, M., Sasmal, D., Mukhopadhyay, K. Optimization and validation of a fast UPLC method for the quantification of anthocyanins.  “International Workshop on Anthocyanins -2011”, Organized by Plants for Human Health Institute, North Carolina, USA. Dated September 11-14, 2011. (Peer Reviewed).
  11. Mazumder, R.; Bhattacharya, S.; Mazumder, A.; Sarkar, B; The More Fast Moving a Brand Is, Greater Is Its Therapeutic Efficacy: Do we Agree?. International Convention of Association for Pharmaceutical Teachers in India (APTI). Vizag. India. Dated: 2nd- 3rd October 2004.

Presentations in National Conferences (06):

  1. Dasgupta S., Sarkar, D., Deb, P. K., Sarkar, B. Influence of solvents on the recovery of polyphenols and bioactivity of Clerodendrum colebrookianum Walp. 6th Convention of Society for Ethnopharmacology, India, 2019 & National Seminar on “Translational Research of Traditionally used Indian medicinal plants with special reference to Tinospora cordifolia”. Organized by: School of Natural Product Studies Jadavpur University, Kolkata, India. Dated: September 07-08, 2019 (SFE-CONV-1962). 
     
  2. Sarkar, D., Dasgupta S., Deb, P. K., Sarkar, B. Ultrasonic assisted rapid extraction of surface Anthocyanin from Ocimum tenuiflorum Linn. and screening of its biological activity. 6th Convention of Society for Ethnopharmacology, India, 2019 & National Seminar on “Translational Research of Traditionally used Indian medicinal plants with special reference to Tinospora cordifolia”. Organized by: School of Natural Product Studies Jadavpur University, Kolkata, India. Dated: September 07-08, 2019 (SFE-CONV-1963).
  3. Anand, A. & Sarkar, B. Phytochemical screening and antioxidant property of anthocyanins extracts from Hibiscus rosa-sinensis. “National Conference on Biotechnology for Sustainable Development (BSD 2015)”. Organized by Centre of Excellence on Bioresources & Bioprospecting (TEQIP II), Department of Bio-Engineering, Birla Institute of Technology, Mesra, Ranchi, Jharkhand. Dated: December 17-19, 2015
  4. Sarkar, B., Kumar, M. & Mukhopadhyay, K. A rapid method for detection and characterization of anthocyanins from Hibiscus, Ocimum and Syzygium species and evaluation of their antioxidant potential. “National Conference on Biotechnology for Sustainable Development (BSD 2015)”. Organized by Centre of Excellence on Bioresources & Bioprospecting (TEQIP II), Department of Bio-Engineering, Birla Institute of Technology, Mesra, Ranchi, Jharkhand. Dated: December 17-19, 2015.
  5. Sarkar, B.; Chandra, R.; Mazumder, R.; Production of Cellulase from Pleurotus ostreatus on spent straw bed. Conference on Bioprocess Engineering and Biotechnology- Trends and Opportunities. B.I.T, Mesra, Ranchi. India. Dated: 17-19th March 2005.
  6. Sarkar, B.; Jayaram Kumar, K.; Bhatnagar, S. P.; Pharmacists in Continuous Food Hygiene & Sanitation Awareness Education (CFHSAE) – An important aid in the implementation of health policies in Jharkhand. 55th Indian Pharmaceutical Congress 2003. Chennai, India. Dated: 19th -21st December 2003
  Member of Professional Bodies
 
  • Registered Pharmacist, Jharkhand State Registration Tribunal, Pharmacy. Jharkhand. India (Reg. No.: 22525-JH-2026, Date: 8.01.2015)
  • Life Member of Indian Pharmaceutical Association (JHA/RANC/ON/LM/000113)
  • Life Member of Association of Pharmaceutical Teachers in India (APTI)(OR/LM-142)
  • Life Member of Indian Pharmaceutical Graduate’s Association (IPGA )(IPGA, LM-1762)
  • Member,Pharmaceutical Society, Birla Institute of Technology, Mesra, Ranchi.
  Current Sponsored Projects
 

Ongoing Projects (INR 98.437 Lakhs):

1. Title: "QbD based approaches and mechanistic studies towards development of verbascoside loaded topical formulations to  treat diabetic wound" (EEQ/2021/000850)
   Grant amount: 40.537 Lakhs
   Sponsoring Agency: DST-SERB Govt. of India (EMEQ Scheme)
   Role: Principal Investigator
   Period: 2022-2025
   Status: On-going

2. Title: "Development of non-destructive process technology for simultaneous micronutrient fortification and bioavailability enhancement in Dal through selective binding of phytic acid" (No. BT/PR38036/PFN/1486/2020)
   Grant amount: 57.90 Lakhs
   Sponsoring Agency: DBT, Govt. of India
   Role: Co-Principal Investigator
   Period: 2021-2024
   Status: On-going

Completed Projects (INR 91.434 Lakhs)

1. Title: "Phyto-chemical characterization of polyphenols in Ocimum tenuiflorum and investigation on its protective potentials against oxidative stress and DNA damage"(File   No.EMR/2016/ 005695)
   Grant amount: 34.23 Lakhs 
   Sponsoring Agency: DST-SERB, Govt. of India
   Role: Principal Investigator
   Period: 2018-2021
   Status: Completed

2. Title: "Design and Synthesis of Substrate Based Peptide Inhibitors of DENV Protease for the Treatment of Dengue Viral Infections" (File No. EMR/2016/005711) 
   Grant amount: 45.604 Lakhs 
   Sponsoring Agency: DST-SERB, Govt. of India
   Role: Co-Principal Investigator
   Period: 2017-2020
   Status: Completed

3. Title: "Study on hepatoprotective properties and expression of antioxidant enzymes by anthocyanins from Ocimum tenuiflorum"
   Grant amount: 0.8 Lakhs
   Sponsoring Agency: Seed Money Scheme, BIT, Mesra, Ranchi
   Role: Principal Investigator
   Period: 2015-2017
   Status: Completed

4. Title:"Study of Antioxidant and DNA Protective Properties of Anthocyanins" 
   Grant amount: 10.8 Lakhs
   Sponsoring Agency: Major Research Project, UGC, Govt. of India
   Role: Co-Principal Investigator
   Period: 2009-2012
   Status: Completed

  Text and Reference Books
 

Book Chapters:

  1. Murtuja S., Shilkar D., Sarkar B., Sinha B.N., Jayaprakash V. (2021) Identification of Dengue NS2B-NS3 Protease Inhibitors Through High-Throughput Virtual Screening—Impacts on Drug Development Against the Dengue Virus. In: Ahmad S.I. (eds) Human Viruses: Diseases, Treatments and Vaccines. Springer, Cham. pp-93-120. https://doi.org/10.1007/978-3-030-71165-8_5
  2. Sarkar, B., Deb, P. K., Banerjee, S. (2021).Oxidative Stress,Inflammasome, and Cancer: Polyphenols May Be the Answer. In: Handbook of Oxidative Stress in Cancer: Mechanistic Aspects.Chakraborti S., Ray B.K., Roychowdhury S. (eds. Springer, Singapore. https://doi.org/10.1007/978-981-15-4501-6_165-1. 
  3. Anand, A. & Sarkar, B (2017). Phytochemical screening and antioxidant property of anthocyanins extracts from Hibiscus rosa-sinensis. In Application of Biotechnology for Sustainable Development. K. Mukhopadhyay et al. (eds.) Page No. 139-147. DOI 10.1007/978-981-10-5538-6_17 (Springer Nature Scientific Publishing Services (P) Ltd.ISBN-10: 9811055378; ISBN-13: 978-9811055379)
  4. Sarkar, B., Kumar, M. & Mukhopadhyay, K (2017). A rapid method for detection and characterization of anthocyanins from Hibiscus, Ocimum and Syzygium species and evaluation of their antioxidant potential. In Application of Biotechnology for Sustainable Development. K. Mukhopadhyay et al. (eds.) Page No. 129-137.  DOI 10.1007/978-981-10-5538-6_17 (Springer Nature Scientific Publishing Services (P) Ltd.ISBN-10: 9811055378; ISBN-13: 978-9811055379)
  Fellow
 
  1. No of UG students guided: 36
  2. No. of PG students guided: 14
  3. No of PhD students: 04 (details as followed)

Sl. No.

Name

Roll No.

Fellowship Details

PhD Thesis Title

  1.  

 

Maria Adhikary*

(Awarded)

 

PhD/BT/10001/2015

UGC- Maulana Azad National Fellowship

 

Wheat grass (Triticum aestivum L.) flavonoids: Analysis of biosynthetic genes and biological activities

  1.  

 

Prashanta Kumar Deb

 

PhD/PH/10003/2018

ICMR SRF in the project:

Development of a Phytopharmaceutical Formulation from the Medicinal Plants of North-eastern India for the Management of Hypertension and Diabetic-cardiovascular Complications (Ref No.45/42/2018/MP/BMS)


Development of phytopharmaceuticals from Clerodendrum glandulosum Lindl.: Investigations toward molecular mechanism of cardioprotection

  1.  

 

Amrita Chatterjee

 

PhD/PH/10001/2019

DST-SERB JRF in the project:

Phyto-chemical characterization of polyphenols in Ocimum tenuiflorum and investigation on its protective potentials against oxidative stress and DNA damage (File No.EMR/2016/ 005695)

Therapeutic targeting of Nrf2-ARE pathway by phytopharmaceuticals derived from Krishna Tulsi (red forma of Ocimum tenuiflorum Linn.) during oxidative stress

  1.  

 

Rajdeep Saha

 

PhD/PH/10003/2019

Institute Research Fellow (MO-2019)

Studies on the effects of bioactive molecules from Clerodendrum glandulosum Lindl. in diabetic wound healing

*Co-guided with Dr. Kunal Mukhopadhyay, Professor, Dept. of Bioengineering

  Member, Editorial Board
 
  1. Reviewer for “Natural Product Research”
  2. Reviewer for “South African Journal of Botany”
  3. Reviewer for “Indian Journal of Pharmaceutical Sciences”
  4. Reviewer for “Chemistry & Biodiversity”
  5. Reviewer for “Planta Medica”
  6. Reviewer for “Chemistry Select”